The condition is called methemoglobinemia, which is a disorder that reduces the amount of oxygen in the blood and body tissues, therefore making the skin appear blue. This then turns the carriers blood into a normal red hue which is then reflected in a change in skin tone. Please copy/paste the following text to properly cite this HowStuffWorks.com article: Dave Roos There are other ways to get blue skin without inheriting it, though. martin fugate was blue from birth, which has nothing to do with inbreeding. Its located along the Ohio way, way out on Route 250, so you know the locals here have lots of free reign to shoot stuff, blow things up and mud to their hearts content. Dennis 4 Comments. That total makes West Virginia the 38th most populous state in the country. Some of the blue people thought the doctor was slightly addled for suggesting that a blue dye could turn them pink. For the first time in their lives, they were pink. The gold of the helmet did not reflect the gold utilized in our colors today. Luke was just as blue as Lake Louise on a cool summer day, doctor Charles H. Behlen II told the Tri-City Herald in 1974. It wasn't always this way. A new playing surface, FieldTurf Revolution 2.5, was installed in 2016, giving West Virginia one of the country's safest and most . But as Kentucky became more populated and more genes came into the Fugate family tree, there were far fewer children born blue. he passed the gene on to his children. February 16, 2012 by Tap Vann. In 2014, the lowest-cost bronze plan in the WV exchange was an average of $280/month, higher than the national average of $249. Once he had the enzyme deficiency isolated, methylene blue sprang to Caweins mind as the perfectly obvious antidote. The blue Fugates who did not wish to remain blue continued to take the pills, and contacted Dr. Cawein and other doctors to get more of them when needed. Eventually, the recessive gene began to disappear once coal mining and the railroad opened the community to outsiders. It run in that generation who lived up and down Ball [Creek]., They looked like anybody else, cept they had the blue color, Stacy says, sitting in a chair in his plaid flannel shirt and suspenders, next to a cardboard box where a small black piglet, kept as a pet, is squealing for his bottle. This results in brown blood giving Caucasian patients a bluish hue to their skin. Dern it, Princeton. When Benjy was born with purple skin, his relatives told the perplexed doctors about his great grandmother Luna Fugate. The good news for those who may still be born expressing the blue gene is that there is a treatment. In the early 1960's, this blue malady caught the attention of Madison Cawein, an inquisitive hematologist from the University of Kentucky. When Two Strangers Lost the Genetic Lottery Martin Fugate arrived in the unsettled frontier of Kentucky in 1820. History Timeline of the Native Indians of West Virginia. Because the Fugate family lived in such an isolated part of the Kentucky, they intermarried with a neighboring family for generations which led to a relatively pure gene pool where the met-H gene appeared much more frequently. Steelworkers Damion Elkins, 50, right, and Edward Clonch, 43, left, in Huntington West Virginia. He knew the same thing was happening in this secluded corner of Appalachia. This small enclave was no longer isolated and they began to disperse and marry outside of their little clan diminishing the effect of the "blue" gene. They are known for being carriers of a genetic trait that led to the blood disorder methemoglobinemia, causing the skin to appear blue. He concluded that inbreeding levels in Appalachia [are neither] unique [n]or particularly common to the region, when compared with those reported for populations elsewhere or at earlier periods in American history.. It was hard to get out, so they intermarried, says Dennis Stacy, a 51-year-old coal miner and amateur genealogist who has filled a loose-leaf notebook with the laboriously traced blood lines of several local families. Have you ever heard the song, Blue Moon of Kentucky? Its pretty well-known and popular. Despite those incredible odds, this is exactly what happened with the Fugates. Martin and Elizabeth set up housekeeping on the banks of Troublesome and began a family. "The beginning of this story is so wild because Martin moved to Kentucky from Europe and married a complete stranger, a nonrelative who just happened to have the same mutation," says Lewis. "There is a clan of partly-colored people in Barbour County often called Guineas, under the erroneous presumption that they are Guinea negroes," observed WV historian Hu Maxwell in the 1890s. Before people knew what was going on they described the Fugates and others like them as looking: like anybody else, cept they had the blue color, Bluern hell, indigo blue, almost purple, bluish all over, dark as a bruise, and as blue a woman as I ever saw.. And shop at Walmart. Google Maps. This genetic defect comes from a rare recessive gene, so most people arent affected by it unless they happen to reproduce with another person who carries it. The region's first coal miners primarily were African Americans, both enslaved and free. When Benjamin "Benjy" Stacy was born in 1975, nurses and doctors were shocked and confused. But by 3 years old and . Martin and Elizabeth had seven children, four of whom were blue; the recessive gene meant there was a 25 percent chance of each pregnancy resulting in a blue child. The doctor was recently approached by the producers of the television show Thats Incredible. They wanted to parade the blue people across the screen in their weekly display of human oddities. His two room log cabin sits in the middle of Laurel Fork Hollow. How far from Flatwoods , ky? They were delighted., They changed colors! remembered Pendergrass. The boy inherited his fathers lankiness and his mothers slightly nasal way of speaking. Google Maps. Aside from the stark discoloration of the carriers skin, there are no serious problems associated with the disease. Population: 7,164Mobile home parks per capita: 2nd in West VirginiaBars per capita: 2nd in the stateWalmart rank: 3rd. Bessie had an iron pot of clothes boiling in her front yard, but she graciously allowed the doctor to draw some of her blood. Today I have a healthy son/nephew who is slightly green in skincolor. The state capital is Charleston. "She had been out in the cold and she was just blue!" recalls Pendergrass, who is now 69 and retired from nursing. The drugs effects are temporary, as methylene blue is normally excreted in the urine. Come on, Grafton rednecks. 5 years ago when I was on a swingerparty she got pregnant with me. You have the most bars and trailer parks per capita in the state, and your high school graduation rate is 70%. She lives alone in one of the. Research on intrafamilial marriage in such enclaves is slim. When you click through real estate links on our site, we earn an affiliate commission. Since there werent any roads or trains near their small community, the kidswere married off to the only people who lived nearby: their cousins. astounding ignorance toward his own countrymen, [are neither] unique [n]or particularly common to the region. One of the girls, the Informant, was discussing an upcoming trip to visit her brother at West Virginia University. Admitted to the union as the 35th state in 1863, it is a relatively small state. T he West Virginia senator Joe Manchin has emerged as one of the biggest stumbling blocks to the passing of Joe Biden's ambitious domestic agenda, declaring he will vote against a key voting. It's a vote cast not just out of allegiance. The Fugate family of Kentucky once lived in the isolated community of Troublesome Creek. Scott's research had found hereditary methemoglobinemia among Alaskan Eskimos and Indians caused by an absence of the enzyme diaphorase from their red blood cells. Edit Old Gold & Blue Page Luna was bluish all over. Princeton is located down on I-77, before you make the climb into Virginia. In 1820, Martin Fugate, who is believed to have been blue, moved to Troublesome Creek from France and just happened to shack up with Elizabeth Smith, who also carried the gene. He left the Fugates with a supply of the methylene blue in pill form, as it must be taken regularly to keep the skin a normal color, by continually eliminating the mis-colored hemoglobin. Population: 6,306Walmart rank: 2ndMobile home parks: 5th in the stateBars per person: 5th in West Virginia. What Happened to the Blue People? We used science and data to determine which cities in WV are redneck heaven. The lightness or darkness of the blue depends on the amount of the substance the person has circulating in them from birth. Luna Stacy possessed the good health common to the blue people, bearing at least 13 children before she died at 84. The last known "blue" Fugate descendant was born in 1975. Finally, one day when the frustrated doctor was idling inside the Hazard clinic, Patrick and Rachel Ritchie walked in. it is a blood disorder in which their blood does not oxygenate correctly. Stumped, the doctor turned to the medical literature for a clue. So, youd think people who are rednecks would be proud to be called a redneck. 2 You couldve done even better than that. It was caused, Scott speculated, by an absence of the enzyme diaphorase from their red blood cells. The following piece was collected at a dinner table with a group of girls out celebrating a friends birthday. 20 Fine Arts Drive, Morgantown, WV 26506. https://artmuseum.wvu.edu. Note: In this instance the reason for cyanosis was not methemoglobinemia but Rh incompatibility. It doesnt mean the condition is gone from the family; theres a chance another child could be born with it, but the incidents of it should be fewer and farther between in the modern era. Such people tend to be very blue only at birth, probably because newborns normally have smaller amounts of diaphorase. It is home to so much creativity, and has been a place of devastating poverty. Her lips were as dark as a bruise. Blood is also likely to be a chocolate brown color instead of bright red in patients with methemoglobinemia. Blue Man Group will rock your world. The story of an Appalachian malady, an inquisitive doctor, and a paradoxical cure. One relative describes her as blue all over, and another calls Luna the bluest woman I ever saw.. Diet: Insects, seeds, and grains. The railroad didnt come through eastern Kentucky until the coal mines were developed around 1912, and it took another 30 or 40 years to lay down roads along the local creeks. The marriage of one of their blue boys, Zachariah, to his mothers sister triggered the line of succession that would result in the birth, more than 100 years later, of Benjy Stacy. New Martinsville is located in the northwestern part of the state, right on the Ohio state line. You know theres lots of rednecks here when you look at the numbers. Funding was made available through a $75 million facilities bond, $25 million in private donations through the Mountaineer Athletic Club and $6 million from West Virginia's multimedia rights contract with IMG. It's true that, through the 19 th century, transportation networks developed slowly in the rugged, westernmost portion of Virginia (incorporated as West Virginia in 1863). Slate is published by The Slate Group, a Graham Holdings Company. Our skimmable newsletter is delivered to your inbox each week, giving you 5 things you need to read and get smarter. Martin Fugate arrived in the unsettled frontier of Kentucky in 1820. Over time, fewer and fewer babies were born blue, and those who were took a methylene blue pill once a day to put the pink back in their cheeks. Appearance: Blue grosbeaks are medium birds about 8 long, large, bright blue, with large silver bills, and chestnut wingbars. Their offspring, often marrying each other, then brought two copies of the recessive gene into the family line, making it much more likely to express itself in their children. Curiosity drove him to Hazard where he was introduced to a nurse, Ruth Pendergrass, who had met a "dark blue" woman. Then, in 2004, Abercrombie & Fitch released a T-shirt emblazoned with a map of the Appalachian state and the words Its all relative in West Virginia. In February, a casting director for the upcoming thriller Shelter put out a call for extras with unusual body shapes, [and] even physical abnormalities to depict West Virginia mountain people. Some sources claim their are no blue . "Methomoglobin is an oxidized form of hemoglobin that has a decreased affinity for oxygen, resulting in a reduced ability to release oxygen to tissues." Everyone around here knows about the blue Fugates, says Hilda Stacy who, at 26, looks more like a sister than a mother to her children. For the Fugates, family members expressed the gene to varying degrees. The Fugate Family of Russell County, Virginia: A Genealogy of the Descendants of Francis, Benjamin, Colbert, Zachariah, Henley & William Fugate, Settlers of Moccasin Valley from 1772. The antidote worked quickly but patients were required to take daily doses as it passed quickly through the urine. Methemoglobinemia is a blood condition, not a skin condition. Theyre prominently featured in reality television. The methaemoglobinaemia condition, or met-H, reduces someones ability to carry oxygen in the blood, leaving it darker than the colour typically found in veins. Scott also concluded that the condition was inherited as a simple recessive trait. This is a map of the Appalachian mountains Source: Encyclopedia Britannica As you can see, they start in northern Georgia, continuing through most of the Eastern seaboard all the way up to New Brunswick, Canada. Instead, football players bore a bronzesque gold helmet emblazoned with a blue outline of the state of West Virginia and the letters "WVU" inside an oval. Laurel Wheeler and family, Buena Vista, Rockbridge County, Virginia. They were like any other 1800s family except theyliked inbreeding. I'm going to assume that by blu. In the Inuit communities, scientists had pinpointed the problem, a deficiency of an enzyme that converted methemoglobin to hemoglobin. Researchers believe this to truly be the case, a result of the family suffering from a genetic condition called methemoglobinemia, which is an excess of methemoglobin in the red blood cells of the body. The entry was on the blue men, not of West Virginia, but of the Mountain State's neighbor, Kentucky, . It's also, in part, out of fear. Only adopted cousins are allowed to marry, while in Vermont, Virginia, and many other states, first cousins can tie the knot. Their inbreeding led to several medical problems and recessive genes being passed down through each child, such as one that gave some of the offspring blue skin. In alphabetical order, these counties are: Barbour, Berkeley, Boone, Braxton, Brooke, Cabell, Calhoun, Clay, Doddridge, Fayette, Gilmer, Grant, Greenbrier, Hampshire, Hancock, Hardy, Harrison, Jackson, Jefferson, Kanawha, Lewis, Lincoln, Logan, Marion, Marshall, Mason, McDowell, Mercer, Mineral, Mingo, Monongalia, Monroe, Morgan, Nicholas, Ohio, They just accepted it as a part of who they were. We threw a lot of criteria at this one in order to get the best, most complete results possible. They were poor people, concurs Nurse Pendergrass, but they were good.References1. 2,999 100 . then I sat down and we began to chart the family." Google Maps. (Martian Survivors). The 76-year-old diva used the less than divine choice of words for the Mountain State in a Twitter against Sen. Joe Manchin torpedoing President Biden's multitrillion-dollar spending plans. All lived in isolation from the world, bunched in log cabins up and down the hollows, and so it was only natural that a boy married the girl next door, even if she had the same last name. Martin and Elizabeth Fugates blue children multiplied in this natural isolation tank. The Blue Ridge was reached in 1670, and in 1671 another expedition encountered the first westward-flowing stream, the New River, in southwestern Virginia. He helped isolate an antidote for cholera, and he did some of the early work on L-dopa, the drug for Parkinsons disease. Wingspan: 6.3-8.3 in (Black-Capped), 5.9-7.9 in (Carolina) Chickadees are tiny little birds that are very easy to recognize because of their "black cap" and black bib. At 30%, nausea, difficulty breathing, and an elevated heart rate start to appear. They lived in isolation and married the girl next door, even if they had the same last name, and consequently passed the gene on to many generations. Blue Hole, West Virginia GPS Coordinates to Blue hole 39.594754,-79.748120 One day, one of the older mountain men cornered the doctor. This brief history has been gleaned from old family records, correspondence with other members, and histories of Ritchie, Barbour, Harrison and Randolph Counties, West Virginia. It was really something exciting to see.. In his research, he found a 1960 article by E. M. Scott that was reported in the Journal of Clinical Investigation. It has nothing to do with melanin, the amino acid that gives people darker skin tones. The Blue Ridge Mountains are a physiographic province of the larger Appalachian Mountains range. Hereditary diaphorase deficiency and methemoglobinemia. If this story were true everyone in Alabama would be blue. there is no "blue-soloution" that turns them back to a "normal" color. The topographic boundary was modified where Route 9 crossed the watershed divide. All rights reserved. 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