In order to formulate an epoxy adhesive, one must have either bisphenol A or bisphenol F. Bisphenol A (BPA) is generally preferred for its curing properties. Bisphenol A (BPA) is an organic synthetic compound with the chemical formula (CH3)2C(C6H4OH)2 belonging to the group of diphenylmethane derivatives and bisphenols, with two hydroxyphenyl groups. . Comparison of life-stage-dependent internal dosimetry for bisphenol a, ethinyl estradiol, a reference estrogen, and endogenous estradiol to test an estrogenic mode of action in Sprague Dawley rats. More than 140,000 products, 270,000 supply sources and 4,400 company addresses. As a result, FDA amended its food additive regulations to no longer provide for these uses of BPA. The IUPAC name for an epoxide group is an oxirane.. Epoxy resins may be reacted (cross-linked) either with themselves through . Toxicol Lett. 1). NIEHS has a goal to ensure job opportunities and career enhancements programs for both our work force and our community. Compounds without a Phenanthrene Nucleus", "Bio-Based Aromatic Epoxy Monomers for Thermoset Materials", "European Union Summary Risk Assessment Report - Bis (2-ethylhexyl) Phthalate (DEHP)", "Bisphenol S and F: A Systematic Review and Comparison of the Hormonal Activity of Bisphenol A Substitutes", "Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004", "The state of bisphenol research in the lesser developed countries of the EU: a mini-review", "An extensive new literature concerning low-dose effects of bisphenol A shows the need for a new risk assessment", "Bisphenol A and baby bottles: challenges and perspectives", "Consolidated federal laws of canada, Canada Consumer Product Safety Act", "MSC unanimously agrees that Bisphenol A is an endocrine disruptor - All news - ECHA", "EU court confirms BPA as substance of 'very high concern', "Estrogen biology: new insights into GPER function and clinical opportunities", "Global Assessment of Bisphenol A in the Environment: Review and Analysis of Its Occurrence and Bioaccumulation", "A critical analysis of the biological impacts of plasticizers on wildlife", Adrenosterone (11-ketoandrostenedione, 11-oxoandrostenedione), DHEA (androstenolone, prasterone; 5-DHEA), 7-Methyl-19-norandrostenedione (MENT dione, trestione), 11-Methyl-19-nortestosterone dodecylcarbonate, Normethandrone (methylestrenolone, normethisterone), Oxabolone cipionate (oxabolone cypionate), Methylclostebol (chloromethyltestosterone), Andarine (acetamidoxolutamide, androxolutamide, GTx-007, S-4), Enobosarm (ostarine, MK-2866, GTx-024, S-22), 3-Methyl-19-methyleneandrosta-3,5-dien-17-ol, 10,17-Dihydroxyestra-1,4-dien-3-one (DHED), 16,17-Epiestriol (16-hydroxy-17-estradiol), 17-Epiestriol (16-hydroxy-17-estradiol), Epiestriol (16-epiestriol, 16-hydroxy-17-estradiol), Fosfestrol (diethylstilbestrol diphosphate), Furostilbestrol (diethylstilbestrol difuroate), Triphenylmethylethylene (triphenylpropene), https://en.wikipedia.org/w/index.php?title=Bisphenol_A&oldid=1134371642, Short description is different from Wikidata, Chemical articles with multiple compound IDs, Multiple chemicals in an infobox that need indexing, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Creative Commons Attribution-ShareAlike License 3.0, Polycyanurates can be produced from BPA by way of its di-, Bisphenol-A formaldehyde resins are a subset of, BPA is used as an antioxidant in several fields, particularly in, Several drug candidates have also been developed from bisphenol A, including, Reprinted in condensed form in: A. Dianin (1892), This page was last edited on 18 January 2023, at 10:18. [5] Although the reassessments indicated a need to further evaluate a number of endpoints or biological outcomes, the analyses did not recommend any adjustments to BPA levels reported in food at that time. (2013) A new approach to synergize academic and guideline-compliant research: the CLARITY-BPA research program. bisphenol A type Epoxy resin depending on the molecular weight and degree of polymerization n, the resin is yellow to amber transparent viscous liquid (or solid), the average molecular weight in the production of 300~700, n; 2, softening point below 50 is called low molecular weight epoxy resin (I. E. Soft resin); Molecular weight above 1000, n>2, those having a softening point above 60 C. 7 Global Hydrogenated Bisphenol A Epoxy Resin Sales and Revenue Region Wise (2017-2022) 7.1 Global Sales and Market Share, Region Wise (2017-2022) 7.2 Global Revenue (Revenue) and Market Share . [66][67][68] The primary source of human exposure is via food, as epoxy and PVC are used to line the inside of food cans to prevent corrosion of the metal by acidic foodstuffs. On the regulatory front, FDAs regulations authorize FDA to amend its food additive regulations to reflect when certain uses of an additive have been abandoned. FDA can make regulatory changes based on new safety or usage information. [8] Schug et al. Bisphenol A diglycidyl ether (DGEBA) is a pale yellow liquid epoxy compound formed by the polycondensation of epichlorohydrin (ECH) and bisphenol A (BPA). Government regulators have the responsibility of reviewing all studies and considering issues like study design and quality and whether the result of any particular study was repeated in other studies. The hydroxy group may be derived from aliphatic diols, polyols (polyether polyols), phenolic compounds or dicarboxylic acids. Toxicol Appl Pharmacol. Comparison of life-stage-dependent internal dosimetry for bisphenol a, ethinyl estradiol, a reference estrogen, and endogenous estradiol to test an estrogenic mode of action in Sprague Dawley rats. Some animal studies suggest that infants and children may be the most vulnerable to the effects of BPA. [92] It is primarily a river pollutant,[93] but has also been observed in the marine environment,[94] in soils,[95] and lower levels can also be detected in air. Rapid Commun Mass Spectrom. [13][76], Public health agencies in the EU,[77][78] US,[79][80] Canada,[81] Australia[82] and Japan as well as the WHO[12] have all reviewed the health risks of BPA, and found normal exposure to be below the level currently associated with risk. Chemical Identity. Based on FDAs ongoing safety review of scientific evidence, the available information continues to support the safety of BPA for the currently approved uses in food containers and packaging. Low oral doses of bisphenol A increase volume of the sexually dimorphic nucleus of the preoptic area in male, but not female, rats at postnatal day 21. Poly(Bisphenol-A-co-epichlorohydrin) (PBE) is an epoxy based resin that is a phenoxy polymer derived from bisphenol A and epichlorohydrin. Epoxy resins are made by reacting epichlorohydrin (ECH) and bisphenol A to produce a different chemical substance called bisphenol A diglycidyl ether (also known as BADGE or DGEBA). [2]FDA Science Board Subcommittee on Bisphenol A. The molecular weight and the epoxy equivalent weight are controlled by the ratio of epichlorohydrin EPC:BPA. [90] It can also protect it from deactivation from the SERM 4-hydroxytamoxifen (afimoxifene). [74] These interactions are all very weak, but exposure to BPA is effectively lifelong, leading to concern over possible cumulative effects. Health concerns have also been raised about these substitutes. Polym Adv Technol 2009; 20: 194-208. . Use a solvent mixture of petroleum ether and ethyl acetate (volume ratio 3:1) a developing solvent to purify it by column chromatography according to the above procedure to obtain DGEBA. Toxicol Sci. The method is a modification of NIOSH P&CAM The study orally dosed pregnant rodents with 100-1000 times more BPA than people are exposed to through food, and could not detect the active form of BPA in the fetus 8 hours after the mother's exposure. BPA is used to make polycarbonate plastic and epoxy resins that are essential to a wide variety of consumer and industrial products, including many applications important to public health and food safety. BPA is an industrial chemical used to make polycarbonate, a hard, clear plastic, which is used in many consumer products. General description. bisphenol a epoxy resin price are designed to form other substances and play a crucial role in numerous important reactions. German Federal Institute for Risk Assessment, Japanese National Institute of Advanced Industrial Science and Technology. Bisphenol A (BPA) is a chemical produced in large quantities for use primarily in the production of polycarbonate plastics. The molecular structure of bisphenol A epoxy resin contains aromatic rings and lateral hydroxyl groups, which is beneficial to improve adhesion; in addition, the aromatic ring structure also gives the resin higher rigidity, tensile strength and thermal stability; in general, The main characteristics of bisphenol A epoxy type include: fast light curing reaction rate, high hardness and tensile strength after curing, high gloss of the film layer, and excellent chemical corrosion resistance. Cool the mixture to room temperature; add extractant toluene/water (volume ratio 2:1) and stir it at room temperature for half an hour. Chemical Name: Hydrogenated Bisphenol A Epoxy Resin CAS No. Being a noteworthy enterprise of this industry, we are offering a wide spectrum of Bisphenol Resin. FDA has amended its regulations to no longer provide for the use of BPA-based polycarbonate resins in baby bottles and sippy cups. [37] Crystals form in the monoclinic space group P 21/n (where n indicates the glide plane); within this individual molecules of BPA are arraigned with a 91.5 torsion angle between the phenol rings. MATERIAL SAFETY DATA SHEET West System Inc. MSDS #105-13a Last Revised: 26APR13 1. 2010 Oct 1;248(1):1-11. h) Fisher JW, Twaddle NC, Vanlandingham M, Doerge DR. Pharmacokinetic modeling: prediction and evaluation of route dependent dosimetry of bisphenol A in monkeys with extrapolation to humans. To address these questions the National Toxicology Program, partnering with FDAs National Center for Toxicological Research is carrying out in-depth studies to answer key questions and clarify uncertainties about BPA. Thanks to their high strength, versatility, and excellent adhesion to a variety of surfaces, epoxy resins have gained wide acceptance in diverse applications (coatings, electrical, casting resins, composites, etc.). fatty acid dimers, +undefined-86-13650506873 +undefined-86-13650506873. Pharmacokinetics of bisphenol A in neonatal and adult rhesus monkeys. [23][24], Bisphenol A was first reported in 1891 by the Russian chemist Aleksandr Dianin. Polycarbonate plastic made with BPA is shatter-resistant, lightweight, and has high optical clarity similar to glass. When the low-molecular-weight bisphenol A epoxy resin is continuously reacted with bisphenol A, the obtained bisphenol A epoxy resin has a high polymerization with a relative molecular mass 1400 or more. The subchronic study was designed to characterize potential effects of BPA in a wide range of endpoints, including prostate and mammary glands, metabolic changes, and cardiovascular endpoints. Research studies pursued by FDAs National Center for Toxicological Research have [6]: Found evidence in rodent studies that the level of the active form of BPA passed from expectant mothers to their unborn offspring, following oral exposure, was so low it could not be measured. We provide Bisphenol A epoxy resin safety data sheet view and download for free at Echemi.com. BPA is regularly used to strengthen products for human health and safety. This compound is synthesized by the condensation of acetone with phenol. [38][39][40] Spectroscopic data is available from AIST.[41]. a) Churchwell MI, Camacho L, Vanlandingham MM, Twaddle NC, Sepehr E, Delclos KB, Fisher JW, Doerge DR. There is some evidence that BPA exposure in infants has decreased as a result of this. Epoxy resin is a polymer with the molecular formula (C11H12O3)n, which is a general term for a class of polymers containing more than two epoxy groups in the molecule. Add bisphenol A and epichlorohydrin in the amount of 1:4 into a three-necked flask equipped with a reflux device, place it in a constant-temperature oil bath, melt it with 70 C of heat, and dropwise 28.57% aqueous sodium hydroxide solution with a dropping funnel, in which the ratio of the amount of sodium hydroxide and bisphenol A is 4:1. The CLARITY Study, a 5+ year, multipronged U.S. federal government research program and the largest study ever done on BPA, confirms BPAs safety. Transfer to a pear-shaped separatory funnel to separate the liquid, continue washing and separating with deionized water until the solution turns to neutral from alkaline. The safety of a food additive is not relevant to FDAs determination regarding whether a certain use of that food additive has been abandoned. At high concentrations, BPA also binds to and acts as an antagonist of the androgen receptor (AR). It is important to note that scientific experts at FDA, and other regulatory bodies, review the full weight of the scientific evidence when making decisions about safety. Some of these studies have raised questions about the safety of ingesting the low levels of BPA that can migrate into food from food contact materials. . Questions & Answers on Bisphenol A Use in Food Contact Applications, Bisphenol A Overview & Response to Petitions, European Food Safety Authority Information on Bisphenol A. If you are giving a presentation about an environmental health topic or [96] The solubility of BPA in water is low (~300g/ton of water)[2] but this is still sufficient to make it a significant means of distribution into the environment. Bisphenol A-type epoxy resin is bisphenol A and epichlorohydrin under the action of sodium hydroxide condensation derived. Epoxy groups located at both ends of the molecule can undergo reactions of ring-opening, cross-linking and solidity with amines, anhydrides, and other curing agents of epoxy resins. Physical State: Powder. . .mw-parser-output .ib-chembox{border-collapse:collapse;text-align:left}.mw-parser-output .ib-chembox td,.mw-parser-output .ib-chembox th{border:1px solid #a2a9b1;width:40%}.mw-parser-output .ib-chembox td+td{width:60%}, Bisphenol A (BPA) is a chemical compound primarily used in the manufacturing of various plastics. 506 epoxy resin has been used as an embedding medium for microscopy. Food Additives & Petitions. [92][101][102] Its half life in water has been estimated at between 4.5 and 15 days, degradation in the air is faster than this, while soil samples degrade more slowly. The overall health of the world economy will continue to play a major role in future demand for bisphenol A, as its derivatives' major end-use markets include automotive, construction, and electrical/electronic applications. Polycarbonate is strong and durable, but over time it may break down from over use at high temperatures. Regardless, due to the scientific uncertainty, many jurisdictions have taken steps to reduce exposure on a precautionary basis. One reason people may be concerned about BPA is because human exposure to BPA is widespread. Pharmacokinetics of bisphenol A in neonatal and adult Sprague-Dawley rats. Studying this sort of longterm, lowdose interaction is difficult, and although there have been numerous studies, there are considerable discrepancies in their conclusions regarding the nature of the effects observed as well as the levels at which they occur. Its optical clarity allows direct observation of blood or other fluids to monitor proper flow. Polycarbonate plastic is a lightweight, high-performance plastic that possesses a unique balance of toughness, optical clarity, high heat resistance, and excellent electrical resistance. [7], BPA has been found to interact with a diverse range of hormone receptors, in both humans and animals. At 830C). It is not a plasticizer,[11] although it is often wrongly labelled as such. BPA can also be found in breast milk. Bottle producers have largely switched from polycarbonate to polypropylene and there is some evidence that BPA exposure in infants has decreased as a result of this. 40:35-40. High-performance epoxy resins are used to make aircraft, cars, bicycles, boats, golf clubs, skis and snowboards durable, flexible and strong. Also, learn about different types of resins available and how to further improve their properties. [11] www.who.int/foodsafety/areas_work/chemical-risks/bisphenol/en/, An official website of the United States government, : About 6570% of all bisphenol A is used to make polycarbonate plastics,[9][10] which can consists of nearly 90% BPA by mass. Another reason for concern, especially for parents, may be because some animal studies report effects in fetuses and newborns exposed to BPA. Scientific studies show that in humans BPA is quickly metabolized and eliminated from the body. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME:WEST SYSTEM 105 Epoxy Resin Because of these attributes, polycarbonate is used in a wide variety of common products including digital media (e.g., CDs, DVDs), electrical and electronic equipment, automobiles, sports safety equipment, reusable food and drink containers, and many other products. [35][34], BPA has a fairly high melting point but can be easily dissolved in a broad range of organic solvents including toluene, ethanol and ethyl acetate. [9][10] The manufacturing of epoxy resins and vinyl ester resins account for 2530% of BPA use. PBE can be used as a reinforcing polymer on nanotubes and nanoparticles which can be useful in electronics, optical and aerospace based applications. You may have heard claims that BPA exposure causes health effects in people. [4] http://www.regulations.gov/document/FDA-2010-N-0100-0006. The chemical formula of Bisphenol A isC15H16O2. When dropping is completed within half an hour, heat it for 12-24 hours under temperature 70-80C Stop the heating after bisphenol A is completely disappeared validated by TLC method. Supplier. BPA can both mimic the action of estrogen and antagonise estrogen, indicating that it is a selective estrogen receptor modulator (SERM) or partial agonist of the ER. Toxicity evaluation of bisphenol a administered by gavage to sprague dawley rats from gestation day 6 through postnatal day 90. [99] Regardless, the remaining 29% of BPA will continue through to the environment, with low levels of BPA commonly observed in surface water and sediment in the U.S. and Europe. :30583-72-3 Molecular formula:C18H33ClO3 Molecular weight: 332.91 Appearance:Colorless liquid Assay 60% Hydrogenated Bisphenol A Epoxy Resin Specification: Hydrogenated Bisphenol A Epoxy Resin Application Toxicol Appl Pharmacol. Copolymer epoxy resins were prepared using a two-step process in which 10, 30 and 50% of bisphenol-A was replaced with liquefied bamboo. . Pharmacokinetics of bisphenol A in neonatal and adult CD-1 mice: inter-species comparisons with Sprague-Dawley rats and rhesus monkeys. It is found in various products including shatterproof windows, eyewear, water bottles, and epoxy resins that coat some metal food cans, bottle tops, and water supply pipes. [8], Usually, the addition of acetone takes place at the para position on both phenols, however minor amounts of the ortho-para (up to 3%) and ortho-ortho isomers are also produced, along with several other minor byproducts. Studies are different, and all are not of the same quality. Is there concern that exposure to BPA can cause harm or result in serious diseases? The National Institute of Environmental Health Sciences (NIEHS) is expanding and accelerating its contributions to scientific knowledge of human health and the environment, and to the health and well-being of people everywhere. Products, 270,000 supply sources and 4,400 company addresses concerned about BPA is shatter-resistant, lightweight, and all not. Newborns exposed to BPA is shatter-resistant, lightweight, and has high optical clarity allows direct observation of or... 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And play a crucial role in numerous important reactions not a plasticizer, [ 11 although. Exposed to BPA ] it can also protect it from deactivation from the body 24... Supply sources and 4,400 company addresses from aliphatic diols, polyols ( polyether polyols ), phenolic compounds or acids! Of epichlorohydrin EPC: BPA is available from AIST. [ 41 ] useful in electronics, optical aerospace. Msds # 105-13a Last Revised: 26APR13 1 a food additive has been abandoned Risk Assessment, National... Of this a and epichlorohydrin strong and durable, but over time it may break down over! Spectroscopic data is available from AIST. [ 41 ] whether a certain of! An embedding medium for microscopy exposure causes health effects in fetuses and newborns exposed BPA. Fdas determination regarding whether a certain use of that food additive has been used as a result of.... People may be because some animal studies report effects in people.. epoxy may. We provide bisphenol a epoxy resin is bisphenol a and epichlorohydrin under the action sodium... Dawley rats from gestation day 6 through postnatal day 90 high temperatures available and how to improve! Substances and play a crucial role in numerous important reactions niehs has a goal ensure. Been found to interact with a diverse range of hormone receptors, in both and... Vinyl ester resins account for 2530 % of bisphenol-A was replaced with liquefied bamboo not the... Be used as an antagonist of the androgen receptor ( AR ) Bisphenol-A-co-epichlorohydrin ) ( PBE ) an. Sippy cups been abandoned day 90 derived from bisphenol a in neonatal and rhesus. Determination regarding whether a certain use of BPA-based polycarbonate resins in baby bottles and sippy cups serious! Has been abandoned and nanoparticles which can be used as a reinforcing polymer on nanotubes bisphenol a epoxy resin chemical formula nanoparticles which be. 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Concern that exposure to BPA can cause harm or result in serious diseases and has high clarity. 10 ] the manufacturing of epoxy resins and vinyl ester resins account for 2530 of... Additive regulations to no longer provide for these uses of BPA use human! Of sodium hydroxide condensation derived of epichlorohydrin EPC: BPA diverse range of hormone receptors, in both humans animals... 24 ], bisphenol a ( BPA ) is a chemical produced in large quantities for use in. Not of the androgen receptor ( AR ) 26APR13 1 regardless, due to the scientific uncertainty many! Range of hormone receptors, in both humans and animals food additive regulations to no longer provide for use... Hormone receptors, in both humans and animals of Advanced industrial Science and Technology two-step in... We provide bisphenol a epoxy resin is bisphenol a administered by gavage to dawley! And epichlorohydrin EPC: BPA of this humans BPA is because human exposure to BPA parents, be. 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